Services for Cytotoxins, Linkers and ADC Conjugation

  • Custom-synthesis of cytotoxins from grams to hundreds of grams
  • MMAE, MMAF and analogs
  • MMAE-Linkers or MMAF-linkers
  • Ansamitocin, Maytansine and derivatives
  • Maytansinoid-Linkers, such as DM1, DM3 and DM4, etc
  • Calicheamicin and analogs
  • Linkers (cleavable and non-cleavable linkers)
  • Customized new toxins, linkers and ADCs
  • ADC conjugations

Custom Synthesis

ACES Pharma is a reliable supplier of high-quality pharmaceutical intermediates, building blocks and
raw materials with competitive prices from grams to hundreds of kilograms. With our vast experience
and state of the art facility, we are capable of synthesizing many difficult custom molecules. We are
committed to provide the best services and products to your research and development programs.

Core Services and Technology

  • Contract custom synthesis and manufacturing (grams to hundreds of kilograms)
  • Contract process research & development
  • Cryogenic reactions up to -100°C
  • Hydrogenation and high pressure reactions
  • Chiral technology from metal-catalyzed and enzymatic reactions
  • Heterocyclic chemistry
  • Chemo-enzymatic process research and development
  • Chemo- and biological production of cytotoxins

Facility and Equipment

  •  18,000 square feet of R & D lab with 100 fume hoods and Kg lab equipments
  •   Pilot plant equipped with cryogenic reactors from 50 L to 250 L;
  •   Glass-lined, stainless steel and ceramic reactors from 50 L to 2000 L;
  •   High pressure reactors from 2 L to 100 L
  •   Well equipped fermentation facility with fermentors from 20 L to 5000 L
  •   HP lab and equipment for toxins, toxin-linkers and ADCs production
  •   Analytical instruments including HPLC, GC, LC-MS, GC-MS, FT-IR and NMR
building blocks of life
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