ACES PHARMA
              building blocks of life
Copyright © 2009 - 2016 ACES Pharma Inc. All rights reserved.
ACES is a leading provider for fully Integrated chemical and biological
services and products in the area of
ANTIBODY DRUG CONJUGATE
(ADC
). We are dedicated to offer numerous payloads/linkers products
and ADC conjugation services as well as
in vitro and in vivo biological
assay. Our proprietary acestatins are composed of  twelve novel
payloads (new versions of auristatins E ,F and dolastatin 10) with
cleavable and non-cleavable linkers. ADCs prepared from acestatins
demonstrated the same or improved efficacy and safety profiles than
ADCs from other auristatins and dolastatins
in vitro and in vivo tumor
models.
ADC CORE TECHNOLOGY
Invent Novel Potent and Efficient Auristatin and
Dolastatin Payloads: Acestatins
(Granted US patent)
ADCs prepared from acestatins demonstrated the
same or improved efficacy and safety profiles than
ADCs from other auristatins and dolastatins
in
vitro
and in vivo tumor models.
Please click to read more.
Our proprietary acestatins are composed of  twelve
novel payloads: new versions of auristatins E ,F
and dolastatin 10) with cleavable and
non-cleavable linkers.
INTEGRATED SERVICE PLATFORM

ADC Conjugation platform with new acestatin    
warheads and linkers:
Conjugation of customer's  antibodies        
with acestatin warheads (Mab-L-acestatin E, F or D)

ADC Conjugation platform with known warheads
and linkers
  • MMAE type ADC (mAb-vc-MMAE)
  • MMAF type ADC (mAb-mc-MMAF)
  • Auristatin type ADC (mAb-vc-auristatin F, C-terminus)
  • DM1-type ADC (mAb-SMCC-DM1)
  • DM3-type ADC (mAb-L-DM3)
  • DM4 type ADC (mAb-SPBD-DM4)
  • DBCO-PEG-mertansine type ADC
  • DBCO-L-payload -mAb
  • Duocarmycin-L-mAb
  • PBDs-type ADC (mAb-L-PBD)

ADC Conjugation kits: including DM1-SMCC, DM4-SMCC, DM4-SPBD, vc-MMAE,
MC-MMAF, vc-auristatin F(C-terminus), L-Duocarmycin, L-PBDs
DBCO-PEG-vc-MMAE for Site-specific Conjugation of Antibody
____________________________________________________________________________________________________________________________________________________________

  • MMAE, MMAF, auristatins E, F, and more
  • MMAE-Linkers MMAF-linkers, and auristatin F-linkers
  • Ansamitocin, maytansinol, and derivatives
  • Maytansine-Linkers
  • DM4, and DM4-linkers
  • Duocarmycin-linkers
  • PBD-linkers
  • Other payloads and linkers
Xenograft tumor model assay

  • DAR values (Drug-antibody ratios)
  • HIC analysis (Hydrophobic ion chromatography)
  • Elisa assay
  • In vitro viability assay (IC50)
  • In vivo Xenograft tumor model evaluation
  • And more
Shelf Products on ADC: (from mg to grams in stock)

  • MMAE, MMAF, auristatins E, F, and more
  • MMAE-Linkers MMAF-linkers, and auristatin F-linkers
  • Ansamitocin, maytansinol, and derivatives
  • Maytansine-Linkers
  • DM4, and DM4-linkers
  • Duocarmycin-linkers
  • PBD-linkers
  • Linkers
Flexible business model for licensing, partnership
and services...
Payloads, payloads-linkers, and demonstrated at
grams to hundreds of gram scales
Custom Synthesis